N-Acetyl-L-aspartic acid
CAS No.:
997-55-7
M. Wt:
175.139
M. Fa:
C6H9NO5
InChI Key:
OTCCIMWXFLJLIA-BYPYZUCNSA-N
Appearance:
White Solid
Names and Identifiers of N-Acetyl-L-aspartic acid
CAS Number |
997-55-7 |
|---|---|
EC Number |
213-643-9 |
MDL Number |
MFCD00020500 |
IUPAC Name |
(2S)-2-acetamidobutanedioic acid |
InChI |
InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1 |
InChIKey |
OTCCIMWXFLJLIA-BYPYZUCNSA-N |
Canonical SMILES |
CC(=O)NC(CC(=O)O)C(=O)O |
Isomeric SMILES |
CC(=O)N[C@@H](CC(=O)O)C(=O)O |
UNII |
445Y04YIWR |
UNSPSC Code |
12352100 |
Physical and chemical properties of N-Acetyl-L-aspartic acid
Acidity coefficient |
3.14±0.10(Predicted) |
|---|---|
Boiling Point |
329.1±52.0 °C at 760 mmHg |
BRN |
1726198 |
Density |
1.5±0.1 g/cm3 |
Exact Mass |
175.048065 |
Flash Point |
152.8±30.7 °C |
Index of Refraction |
1.538 |
LogP |
-0.09 |
Melting Point |
137 - 140 °C |
Merck |
13,845 |
Molecular Formula |
C6H9NO5 |
Molecular Weight |
175.139 |
optical activity |
[α]20/D +12±1°, c = 2% in 6 M HCl |
PSA |
103.70000 |
Solubility |
675 mg/mL |
Specific rotation |
52 º (c=1, HAc) |
Storage condition |
Sealed in dry,Room Temperature |
Vapour Pressure |
0.0±1.6 mmHg at 25°C |
Safety Information of N-Acetyl-L-aspartic acid
Applications of N-Acetyl-L-aspartic acid
The applications of N-Acetyl-L-aspartic acid are diverse:
- Neuroscience Research: It serves as a biomarker in magnetic resonance spectroscopy for diagnosing brain injuries and diseases.
- Clinical Diagnostics: Decreased levels of N-Acetyl-L-aspartic acid are often indicative of neurological disorders, making it valuable for clinical assessments.
- Potential Therapeutics: Research is ongoing into its therapeutic potential for cognitive enhancement and neuroprotection.
Interaction Studies of N-Acetyl-L-aspartic acid
Studies on N-Acetyl-L-aspartic acid interactions have revealed its role in modulating neuronal activity and neurotransmitter release. It may interact with metabotropic glutamate receptors, influencing synaptic plasticity and cognitive functions. Additionally, elevated levels of this compound have been linked to improved working memory and educational attainment in humans.
Biological Activity of N-Acetyl-L-aspartic acid
N-Acetyl-L-aspartic acid serves multiple biological functions:
- Osmolyte: It helps maintain fluid balance in neurons.
- Lipid Synthesis: It acts as a source of acetate for lipid and myelin synthesis in oligodendrocytes.
- Neurotransmitter Precursor: It is a precursor for N-acetylaspartylglutamate, contributing to neurotransmission.
- Energy Production: It plays a role in energy metabolism from glutamate in neuronal mitochondria.
Moreover, alterations in N-Acetyl-L-aspartic acid levels have been associated with various neurological disorders, including Canavan disease and neurodegenerative conditions like Alzheimer's disease.
Physical sample testing spectrum (NMR) of N-Acetyl-L-aspartic acid
Cas:19146-51-1
Cas:3106-85-2
Cas:17336-14-0
Cas:56-84-8