structure of Flazin

Flazin

CAS No.: 100041-05-2
M. Wt: 308.28800
M. Fa: C17H12N2O4
InChI Key: USBWYUYKHHILLZ-UHFFFAOYSA-N

Names and Identifiers of Flazin

CAS Number

100041-05-2

IUPAC Name

1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid

InChI

InChI=1S/C17H12N2O4/c20-8-9-5-6-14(23-9)16-15-11(7-13(19-16)17(21)22)10-3-1-2-4-12(10)18-15/h1-7,18,20H,8H2,(H,21,22)

InChIKey

USBWYUYKHHILLZ-UHFFFAOYSA-N

Canonical SMILES

C1=CC=C2C(=C1)C3=CC(=NC(=C3N2)C4=CC=C(O4)CO)C(=O)O

Physical and chemical properties of Flazin

Boiling Point

657.1ºC at 760mmHg

Density

1.513g/cm3

Exact Mass

308.08000

Flash Point

351.2ºC

Index of Refraction

1.771

LogP

3.16660

Melting Point

231 - 233 °C

Molecular Formula

C17H12N2O4

Molecular Weight

308.28800

PSA

99.35000

Vapour Pressure

3.69E-18mmHg at 25°C

Applications of Flazin

Flazin has several promising applications:

  • Nutraceuticals: Due to its health benefits related to diabetes management and lipid metabolism, flazin is being explored as a dietary supplement or functional food ingredient.
  • Pharmaceuticals: Its potential as a therapeutic agent for metabolic disorders positions flazin as a candidate for drug development targeting diabetes and related complications.
  • Research: Flazin serves as a valuable compound for studying metabolic pathways and disease mechanisms due to its unique biochemical properties.

Interaction Studies of Flazin

Research indicates that flazin interacts with various biomolecules, particularly proteins involved in metabolic processes. Molecular dynamics simulations have revealed that flazin binds to key residues in insulin, affecting its glycation state. Additionally, studies on its interaction with lipid droplets suggest that flazin alters lipid metabolism by modulating gene expression related to lipolysis and lipogenesis.

Biological Activity of Flazin

Flazin exhibits a range of biological activities, including:

  • Non-Enzymatic Glycation Inhibition: Flazin effectively inhibits the glycation of proteins such as bovine serum albumin and insulin, which is essential for managing diabetes.
  • Lipid Metabolism Regulation: It significantly reduces triglyceride levels and alters lipid droplet morphology, contributing to improved lipid profiles in cells.
  • Antioxidant Properties: Flazin demonstrates antioxidant activity by scavenging reactive nitrogen species, thereby protecting cells from oxidative stress.
  • Potential Anti-HIV Activity: Preliminary studies suggest that flazin may possess anti-HIV properties, although further research is required to substantiate these claims.