5-Bromo-1-methylindoline
Names and Identifiers of 5-Bromo-1-methylindoline
CAS Number |
99848-78-9 |
|---|---|
MDL Number |
MFCD09817498 |
IUPAC Name |
5-bromo-1-methyl-2,3-dihydroindole |
InChI |
InChI=1S/C9H10BrN/c1-11-5-4-7-6-8(10)2-3-9(7)11/h2-3,6H,4-5H2,1H3 |
InChIKey |
YIRSVRZXIXHOSN-UHFFFAOYSA-N |
Canonical SMILES |
CN1CCC2=CC(Br)=CC=C21 |
UNSPSC Code |
12352100 |
Physical and chemical properties of 5-Bromo-1-methylindoline
Acidity coefficient |
5.30±0.20(Predicted) |
|---|---|
Boiling Point |
296.9±33.0 °C at 760 mmHg |
Density |
1.5±0.1 g/cm3 |
Exact Mass |
210.999649 |
Flash Point |
133.3±25.4 °C |
Index of Refraction |
1.599 |
LogP |
2.94 |
Molecular Formula |
C9H10BrN |
Molecular Weight |
212.086 |
PSA |
3.24000 |
Vapour Pressure |
0.0±0.6 mmHg at 25°C |
Safety Information of 5-Bromo-1-methylindoline
Applications of 5-Bromo-1-methylindoline
5-Bromo-1-methylindoline has several applications, particularly in:
- Pharmaceutical Development: Due to its biological activity, it is a candidate for developing new anticancer agents.
- Organic Synthesis: It serves as an intermediate for synthesizing more complex organic molecules.
- Material Science: Its unique properties may also be explored in the development of novel materials with specific electronic or optical characteristics.
Interaction Studies of 5-Bromo-1-methylindoline
Studies on the interactions of 5-bromo-1-methylindoline with biological targets have revealed its potential mechanisms of action. For example, certain derivatives have been shown to induce apoptosis in cancer cells through mitochondrial pathways, suggesting that they may disrupt cellular processes critical for cancer cell survival. Further research into its interactions with specific proteins and enzymes could provide insights into its therapeutic potential.
Biological Activity of 5-Bromo-1-methylindoline
Research indicates that 5-bromo-1-methylindoline and its derivatives exhibit significant biological activities. Notably, compounds with brominated indole structures have been studied for their antiproliferative effects against various cancer cell lines. For instance, derivatives of 5-bromo-indole have shown comparable or superior activity compared to established chemotherapeutics like cisplatin, while exhibiting lower toxicity to normal cells. This suggests potential as drug candidates in cancer therapy.
Physical sample testing spectrum (NMR) of 5-Bromo-1-methylindoline

Cas:106883-07-2